What Are the Differences Between PRP and Mesotherapy?
What Are PRP and Mesotherapy?
PRP (Platelet-Rich Plasma)
PRP is a regenerative procedure that uses the patient’s own blood to isolate platelet-rich plasma, which is then injected back into the skin or scalp. Platelets contain growth factors that stimulate tissue repair, collagen production, and cellular regeneration.
Mesotherapy
Mesotherapy is a technique where a cocktail of vitamins, minerals, amino acids, hyaluronic acid, and antioxidants is injected into the mesodermal layer of the skin to nourish and revitalize it. It is used to hydrate, brighten, and strengthen the skin barrier.
Key Differences in Ingredients and Application
|
Feature |
PRP |
Mesotherapy |
|
Content |
Autologous platelets and growth factors from the patient’s own blood |
Ready-made blends of vitamins, minerals, amino acids, hyaluronic acid |
|
Source |
100% patient-derived |
Topical ampoules; may be customized |
|
Application Method |
Microneedling or direct microinjection |
Microinjections (needle or mesogun) |
|
Sterility Requirements |
Very high (due to blood handling) |
Moderate |
|
Primary Action |
Stimulates cellular regeneration |
Provides targeted nutrients and hydration |
Mechanism of Action
- PRP activates fibroblasts and stem cells via natural growth factors, promoting deep tissue repair and collagen remodeling.
- Mesotherapy delivers active compounds directly into the skin to improve hydration, tone, and surface texture.
Use Case Comparison: Where Each Excels
|
Concern |
PRP |
Mesotherapy |
|
Skin rejuvenation |
✅ |
✅ |
|
Skin tone brightening |
⚪ Moderate |
✅ Strong |
|
Under-eye circles & hollows |
✅ |
✅ |
|
Acne scars & skin texture |
✅ Deep regeneration |
⚪ Surface support |
|
Fine lines & wrinkles |
✅ |
✅ |
|
Hair loss (androgenic alopecia) |
✅ Highly effective |
✅ Supportive |
|
Skin hydration |
⚪ Limited |
✅ Direct hydration |
|
Collagen stimulation |
✅ Strong |
⚪ Indirect or mild |
PRP is ideal for deep regeneration, while mesotherapy is better for surface-level support and hydration.
Number of Sessions and Duration of Results
- PRP
- 3–4 sessions, every 3–4 weeks
- Effects last 6–12 months
- Visible results start within 2–3 weeks
- Mesotherapy
- 4–6 sessions, every 1–2 weeks
- Effects last 2–4 months
- Visible improvement from session 1 or 2
Can PRP and Mesotherapy Be Combined?
Yes! They can be used together or alternately to enhance results. For example:
- PRP stimulates cellular renewal
- Mesotherapy adds moisture and nutrients
This combination is often used in anti-aging protocols, especially in the face, neck, and scalp.
Which Should You Choose?
|
Condition |
Best Choice |
|
Deep acne or surgical scars |
✅ PRP |
|
Dull, dehydrated skin |
✅ Mesotherapy |
|
Hair loss (male/female pattern) |
✅ PRP (first-line) |
|
Uneven skin tone or pigmentation |
✅ Mesotherapy |
|
Under-eye rejuvenation |
✅ PRP + Mesotherapy |
|
General skin maintenance |
✅ Mesotherapy |